From Literature to Hypotheses: An AI Co-Scientist System for Biomarker-Guided Drug Combination Hypothesis Generation
arXiv:2603.00612v1 Announce Type: new Abstract: The rapid growth of biomedical literature and curated databases has made it increasingly difficult for researchers to systematically connect biomarker mechanisms to actionable drug combination hypotheses. We present AI Co-Scientist (CoDHy), an interactive, human-in-the-loop system...
Piecing Together Cross-Document Coreference Resolution Datasets: Systematic Dataset Analysis and Unification
arXiv:2603.00621v1 Announce Type: new Abstract: Research in CDCR remains fragmented due to heterogeneous dataset formats, varying annotation standards, and the predominance of the CDCR definition as the event coreference resolution (ECR). To address these challenges, we introduce uCDCR, a unified...
Polynomial Mixing for Efficient Self-supervised Speech Encoders
arXiv:2603.00683v1 Announce Type: new Abstract: State-of-the-art speech-to-text models typically employ Transformer-based encoders that model token dependencies via self-attention mechanisms. However, the quadratic complexity of self-attention in both memory and computation imposes significant constraints on scalability. In this work, we propose...
LaSTR: Language-Driven Time-Series Segment Retrieval
arXiv:2603.00725v1 Announce Type: new Abstract: Effectively searching time-series data is essential for system analysis, but existing methods often require expert-designed similarity criteria or rely on global, series-level descriptions. We study language-driven segment retrieval: given a natural language query, the goal...
MedGPT-oss: Training a General-Purpose Vision-Language Model for Biomedicine
arXiv:2603.00842v1 Announce Type: new Abstract: Biomedical multimodal assistants have the potential to unify radiology, pathology, and clinical-text reasoning, yet a critical deployment gap remains: top-performing systems are either closed-source or computationally prohibitive, precluding the on-premises deployment required for patient privacy...
Prompt Sensitivity and Answer Consistency of Small Open-Source Large Language Models on Clinical Question Answering: Implications for Low-Resource Healthcare Deployment
arXiv:2603.00917v1 Announce Type: new Abstract: Small open-source language models are gaining attention for low-resource healthcare settings, but their reliability under different prompt phrasings remains poorly understood. We evaluated five open-source models (Gemma 2 2B, Phi-3 Mini 3.8B, Llama 3.2 3B,...
The Aftermath of DrawEduMath: Vision Language Models Underperform with Struggling Students and Misdiagnose Errors
arXiv:2603.00925v1 Announce Type: new Abstract: Effective mathematics education requires identifying and responding to students' mistakes. For AI to support pedagogical applications, models must perform well across different levels of student proficiency. Our work provides an extensive, year-long snapshot of how...
Towards Orthographically-Informed Evaluation of Speech Recognition Systems for Indian Languages
arXiv:2603.00941v1 Announce Type: new Abstract: Evaluating ASR systems for Indian languages is challenging due to spelling variations, suffix splitting flexibility, and non-standard spellings in code-mixed words. Traditional Word Error Rate (WER) often presents a bleaker picture of system performance than...
Qayyem: A Real-time Platform for Scoring Proficiency of Arabic Essays
arXiv:2603.01009v1 Announce Type: new Abstract: Over the past years, Automated Essay Scoring (AES) systems have gained increasing attention as scalable and consistent solutions for assessing the proficiency of student writing. Despite recent progress, support for Arabic AES remains limited due...
StaTS: Spectral Trajectory Schedule Learning for Adaptive Time Series Forecasting with Frequency Guided Denoiser
arXiv:2603.00037v1 Announce Type: new Abstract: Diffusion models have been used for probabilistic time series forecasting and show strong potential. However, fixed noise schedules often produce intermediate states that are hard to invert and a terminal state that deviates from the...
Attn-QAT: 4-Bit Attention With Quantization-Aware Training
arXiv:2603.00040v1 Announce Type: new Abstract: Achieving reliable 4-bit attention is a prerequisite for end-to-end FP4 computation on emerging FP4-capable GPUs, yet attention remains the main obstacle due to FP4's tiny dynamic range and attention's heavy-tailed activations. This paper presents the...
Breaking the Factorization Barrier in Diffusion Language Models
arXiv:2603.00045v1 Announce Type: new Abstract: Diffusion language models theoretically allow for efficient parallel generation but are practically hindered by the "factorization barrier": the assumption that simultaneously predicted tokens are independent. This limitation forces a trade-off: models must either sacrifice speed...
REMIND: Rethinking Medical High-Modality Learning under Missingness--A Long-Tailed Distribution Perspective
arXiv:2603.00046v1 Announce Type: new Abstract: Medical multi-modal learning is critical for integrating information from a large set of diverse modalities. However, when leveraging a high number of modalities in real clinical applications, it is often impractical to obtain full-modality observations...
Knowledge-guided generative surrogate modeling for high-dimensional design optimization under scarce data
arXiv:2603.00052v1 Announce Type: new Abstract: Surrogate models are widely used in mechanical design and manufacturing process optimization, where high-fidelity computational models may be unavailable or prohibitively expensive. Their effectiveness, however, is often limited by data scarcity, as purely data-driven surrogates...
Mag-Mamba: Modeling Coupled spatiotemporal Asymmetry for POI Recommendation
arXiv:2603.00053v1 Announce Type: new Abstract: Next Point-of-Interest (POI) recommendation is a critical task in location-based services, yet it faces the fundamental challenge of coupled spatiotemporal asymmetry inherent in urban mobility. Specifically, transition intents between locations exhibit high asymmetry and are...
Expert Divergence Learning for MoE-based Language Models
arXiv:2603.00054v1 Announce Type: new Abstract: The Mixture-of-Experts (MoE) architecture is a powerful technique for scaling language models, yet it often suffers from expert homogenization, where experts learn redundant functionalities, thereby limiting MoE's full potential. To address this, we introduce Expert...
MAML-KT: Addressing Cold Start Problem in Knowledge Tracing for New Students via Few-Shot Model-Agnostic Meta Learning
arXiv:2603.00137v1 Announce Type: new Abstract: Knowledge tracing (KT) models are commonly evaluated by training on early interactions from all students and testing on later responses. While effective for measuring average predictive performance, this evaluation design obscures a cold start scenario...
OSF: On Pre-training and Scaling of Sleep Foundation Models
arXiv:2603.00190v1 Announce Type: new Abstract: Polysomnography (PSG) provides the gold standard for sleep assessment but suffers from substantial heterogeneity across recording devices and cohorts. There have been growing efforts to build general-purpose foundation models (FMs) for sleep physiology, but lack...
Task-Driven Subspace Decomposition for Knowledge Sharing and Isolation in LoRA-based Continual Learning
arXiv:2603.00191v1 Announce Type: new Abstract: Continual Learning (CL) requires models to sequentially adapt to new tasks without forgetting old knowledge. Recently, Low-Rank Adaptation (LoRA), a representative Parameter-Efficient Fine-Tuning (PEFT) method, has gained increasing attention in CL. Several LoRA-based CL methods...
CoPeP: Benchmarking Continual Pretraining for Protein Language Models
arXiv:2603.00253v1 Announce Type: new Abstract: Protein language models (pLMs) have recently gained significant attention for their ability to uncover relationships between sequence, structure, and function from evolutionary statistics, thereby accelerating therapeutic drug discovery. These models learn from large protein databases...
Scalable Gaussian process modeling of parametrized spatio-temporal fields
arXiv:2603.00290v1 Announce Type: new Abstract: We introduce a scalable Gaussian process (GP) framework with deep product kernels for data-driven learning of parametrized spatio-temporal fields over fixed or parameter-dependent domains. The proposed framework learns a continuous representation, enabling predictions at arbitrary...
Polynomial Surrogate Training for Differentiable Ternary Logic Gate Networks
arXiv:2603.00302v1 Announce Type: new Abstract: Differentiable logic gate networks (DLGNs) learn compact, interpretable Boolean circuits via gradient-based training, but all existing variants are restricted to the 16 two-input binary gates. Extending DLGNs to Ternary Kleene $K_3$ logic and training DTLGNs...
When does Chain-of-Thought Help: A Markovian Perspective
arXiv:2603.00306v1 Announce Type: new Abstract: Chain-of-Thought (CoT) prompting is a widely used inference-time technique for improving reasoning, yet its gains are uneven across tasks. We analyze when and why CoT helps by modeling the step-wise reasoning trajectory as a Markov...
Vectorized Adaptive Histograms for Sparse Oblique Forests
arXiv:2603.00326v1 Announce Type: new Abstract: Classification using sparse oblique random forests provides guarantees on uncertainty and confidence while controlling for specific error types. However, they use more data and more compute than other tree ensembles because they create deep trees...
Quantifying Catastrophic Forgetting in IoT Intrusion Detection Systems
arXiv:2603.00363v1 Announce Type: new Abstract: Distribution shifts in attack patterns within RPL-based IoT networks pose a critical threat to the reliability and security of large-scale connected systems. Intrusion Detection Systems (IDS) trained on static datasets often fail to generalize to...
Deep Learning-Based Meat Freshness Detection with Segmentation and OOD-Aware Classification
arXiv:2603.00368v1 Announce Type: new Abstract: In this study, we present a meat freshness classification framework from Red-Green-Blue (RGB) images that supports both packaged and unpackaged meat datasets. The system classifies four in-distribution (ID) meat classes and uses an out-of-distribution (OOD)-aware...
Improving Full Waveform Inversion in Large Model Era
arXiv:2603.00377v1 Announce Type: new Abstract: Full Waveform Inversion (FWI) is a highly nonlinear and ill-posed problem that aims to recover subsurface velocity maps from surface-recorded seismic waveforms data. Existing data-driven FWI typically uses small models, as available datasets have limited...
Hereditary Geometric Meta-RL: Nonlocal Generalization via Task Symmetries
arXiv:2603.00396v1 Announce Type: new Abstract: Meta-Reinforcement Learning (Meta-RL) commonly generalizes via smoothness in the task encoding. While this enables local generalization around each training task, it requires dense coverage of the task space and leaves richer task space structure untapped....
Physics-Aware Learnability: From Set-Theoretic Independence to Operational Constraints
arXiv:2603.00417v1 Announce Type: new Abstract: Beyond binary classification, learnability can become a logically fragile notion: in EMX, even the class of all finite subsets of $[0,1]$ is learnable in some models of ZFC and not in others. We argue the...
Weight Updates as Activation Shifts: A Principled Framework for Steering
arXiv:2603.00425v1 Announce Type: new Abstract: Activation steering promises to be an extremely parameter-efficient form of adaptation, but its effectiveness depends on critical design choices -- such as intervention location and parameterization -- that currently rely on empirical heuristics rather than...